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Titolo	Electrolyte concentration during haemodialysis and QT interval prolongation in uraemic patients
Autore	Simonetta Genovesi, Chiara Dossi, Maria Rosa Viganò, Eleonora Galbiati, Federico Prolo, Andrea Stella, Marco Stramba-Badiale
Referenza	Europace 2008; doi: 10.1093/europace/eun028
Contenuto	Aims To assess the effect of different combinations of potassium and calcium concentrations on QT interval in the dialysis bath in uraemic patients. Methods and results Sixteen haemodialysis (HD) patients underwent a 24 h Holter recording before and during HD sessions with six randomized combinations of electrolytes concentrations of the dialysis bath (Kþ, 2 and 3 mmol/L; Ca2þ, 1.25, 1.5, and 1.75 mmol/L). The effect of different dialysis baths on QT interval was significant (P , 0.05). The longest mean QTc was observed with the lowest Kþ (2 mmol/L) and Ca2þ concentrations (1.25 mmol/L), whereas the shortest mean QTc was observed with the highest Kþ (3 mmol/L) and Ca2þ concentrations (1.75 mmol/L). QTc was .440 ms in 9 of 16 patients (56%) at the lowest Ca2þ and Kþ concentrations, and in 3 of 16 patients (18%) at the highest electrolytes level. Changes in QTc during the HD sessions were inversely correlated with that in total Ca and Ca2þ plasma concentrations (P , 0.0001). Conclusion Changes in ventricular repolarization duration associated with HD largely depend on the concentrations of Ca2þ and Kþ in the dialysis bath. These findings may have important implications for the choice of the electrolytes concentration of the dialysis bath during the HD session.
Data	27.02.2008

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