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Titolo Progression of coronary artery calcification and cardiac events in patients with chronic renal disease not receiving dialysis
Autore Domenico Russo1 , Salvatore Corrao2 , Yuri Battaglia1 , Michele Andreucci3 , Antonella Caiazza1 , Angelo Carlomagno4 , Monica Lamberti5 , Nicoletta Pezone1 , Andrea Pota1 , Luigi Russo1 , Maurizio Sacco5 and Bernadette Scognamiglio1 - 1 Department of Nephrology, University of Naples, Naples, Italy; 2 Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy; 3 Department of Nephrology, University of Catanzaro, Catanzaro, Italy; 4 Department of Cardiology, University of Naples, Naples, Italy and5 Department of Radiology, San Gennaro Hospital, Naples, Italy
Referenza Kidney International 2011; doi:10.1038/ki.2011.69

We tested for the presence of coronary calcifications in patients with chronic renal disease not on dialysis and studied its progression in 181 consecutive non-dialyzed patients who were followed for a median of 745 days. Coronary calcifications (calcium score) were tallied in Agatston units by computed tomography, and the patients were stratified into two groups by their baseline calcium score (100 U or less and over 100 U). Survival was measured by baseline calcium score and its progression. Cardiac death and myocardial infarction occurred in 29 patients and were significantly more frequent in those patients with calcium scores over 100 U (hazard ratio of 4.11). With a calcium score of 100 U or less, the hazard ratio for cardiac events was 0.41 and 3.26 in patients with absent and accelerated progression, respectively. Thus, in non-dialyzed patients, the extent of coronary calcifications was associated to cardiac events, and progression was an independent predictive factor of cardiac events mainly in less calcified patients. Hence, assessment of coronary calcifications and progression might be useful for earlier management of risk factors and guiding decisions for prevention of cardiac events in this patient population.

Data 13.01.2012
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