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Titolo Association between Markers of Inflammation, Fibrosis and Hypervolemia in Peritoneal Dialysis Patients
Autore Azim S. Gangji a, b K. Scott Brimble a Peter J. Margetts a - a Division of Nephrology, McMaster University and St. Joseph?s Healthcare, and b Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ont. , Canada
Referenza Blood Purif 2009; 28: 354-358
Contenuto Background/Aim: Volume expansion in peritoneal dialysis (PD) patients is associated with left ventricular hypertrophy. The link between inflammation and hypervolemia has not been extensively studied. The aim of this study was to determine if an association exists between hypervolemia and markers of inflammation in PD patients. Methods: In this cross-sectional study of 22 prevalent PD patients, volume was determined by bioelectrical impedance analysis. Serum and peritoneal effluent interleukin-6 (IL-6) and peritoneal transforming growth factor (TGF)- _ 1 were measured. A fast peritoneal equilibration test determined peritoneal transport status. Results: Bioimpedance-derived measures of hypervolemia correlated with peritoneal effluent IL-6 and TGF- _ 1 . Peritoneal IL-6 was also associated with high peritoneal transport status. Conclusions: Markers of inflammation and fibrosis (peritoneal IL-6 and TGF- _ 1 ) are associated with markers of hypervolemia.
Data 03.09.2009
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