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Titolo Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease
Autore Patrick H. Pun1,4, Thomas R. Smarz2,4, Emily F. Honeycutt3, Linda K. Shaw3, Sana M. Al-Khatib1 and John P. Middleton1 - 1Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; 2Metrolina Nephrology Associates, Charlotte, North Carolina, USA and 3Duke Clinical Research Institute, Durham, North Carolina, USA
Referenza Kidney International (2009); 76: 652-658
Contenuto Sudden cardiac death is the most common cause of mortality among patients with end-stage kidney disease maintained on hemodialysis. To examine whether this increased risk is also seen with less advanced kidney disease, we studied the relationship between glomerular filtration rate and risk of sudden cardiac death in patients with moderate kidney disease and known coronary artery disease. This retrospective longitudinal study encompassed 19,440 consecutive patients who underwent cardiac catheterization at a single academic institution. There were 522 adjudicated sudden cardiac death events, yielding an overall rate of 4.6 events per 1000 patient years. This figure reflected rates of 3.8 events in 14,652 patients with estimated glomerular filtration rates (eGFR) X60 (stage 2 CKD or better) and 7.9 events in 4788 patients with glomerular filtration rates o60 (stage 3-5 CKD), all normalized to 1000 patient-years. After adjusting for differences in known cardiac risk factors and other covariates in a multivariate Cox proportional hazards model, the eGFR was independently associated with sudden cardiac death (hazard ratio (HR)ΒΌ1.11 per 10ml/min decline in the eGFR). Our analysis found that reductions in the Egfr in CKD stages 3-5 are associated with a progressive increase in risk of sudden cardiac death in patients with coronary artery disease. Additional studies are needed to better characterize the mechanisms by which reduced kidney function increases this risk.
Data 03.09.2009
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