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Titolo Interleukin-6 Is a Better Predictor of Mortality as Compared to C-Reactive Protein, Homocysteine, Pentosidine and Advanced Oxidation Protein Products in Hemodialysis Patients
Autore Maria A. Pachaly a, c, Marcelo M. do Nascimentoa, c, d, Mohamed E. Sulimand, Shirley Y. Hayashid, Miguel C. Riellab, Roberto C. Manfroc, Peter Stenvinkeld, Bengt Lindholmd - Maria A. Pachaly a, c, Marcelo M. do Nascimentoa, c, d, Mohamed E. Sulimand, Shirley Y. Hayashid, Miguel C. Riellab, Roberto C. Manfroc, Peter Stenvinkeld, Bengt Lindholmd
Referenza Blood Purif 2008; 26: 204-210
Contenuto Inflammatory markers predict mortality in hemodialysis (HD) patients, whereas a possible association between oxidative stress (OS) markers and survival is less clear. We assessed the impact on all-cause mortality of baseline inflammatory [high-sensitivity C-reactive protein and interleukin-6 (IL-6)] and OS markers (advanced oxidation protein products, pentosidine, homocysteine) in 112 HD patients. We found no significant correlations between inflammatory and OS markers. During the 5.5 years of follow-up, 51 patients died. In a Kaplan-Meier analysis, the survival rate was reduced in patients with IL-6 higher than the median (IL-6 >4.2 pg/ml) (log- rank = 6.47; p = 0.01), in diabetics (log-rank = 12.26; p = 0.0005) and in older patients (log-rank = 11.22; p = 0.0008). Moreover, in Cox analysis only IL-6 and age were independently associated with mortality. We conclude that in this group of prevalent Brazilian HD patients, IL-6 was a better predictor of survival than other inflammatory and OS markers.
Data 23.06.2008
 
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