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Titolo Association between high ultrafiltration rates and mortality in uraemic patients on regular haemodialysis. A 5-year prospective observational multicentre study
Autore Ezio Movilli, Paola Gaggia, Roberto Zubani, Corrado Camerini, Valerio Vizzardi, Giovanni Parrinello, Silvana Savoldi, Marie Stephanie Fischer, Francesco Londrino and Giovanni Cancarini
Referenza Nephrol Dial Transplant 2007; 22: 3547-3552
Contenuto Background. High ultrafiltration rate on haemodialysis (HD) stresses the cardiovascular system and could have a negative effect on survival. Methods. The effect of ultrafiltration rate (UFR; ml/h/ kg BW) on mortality was prospectively evaluated in a cohort of 287 prevalent uraemic patients in regular HD from 1 January 2000 to 31 December 2005. Patients: 165 men and 122 women, age 66_13 years, on regular HD for at least 6 months, median: 48 months (range 6-372 months). Mean UFR was 12.7_3.5 ml/h/kg BW, Kt/V: 1.27_0.13, body weight (BW): 62_13 kg, PCRn: 1.11_0.20 g/kg/day, duration of dialysis: median 240 min (range 180-300 min), mean arterial blood pressure (MAP) 99_9 mm/Hg. One hundred and forty nine patients (52%) died, mainly for cardiovascular reasons (69%). Multivariate Cox regression analysis was utilized to evaluate the effect on mortality of UFR, age, sex, dialytic vintage, cardiovascular disease (CVD), diabetes, dialysis modality, duration of HD, BW, interdialytic weight gain (IWG), body mass index (BMI), MAP, pulse pressure (PP), Kt/V, PCRn. Results. Age (HR 1.06; CI 1.04-1.08; P<0.0001), PCRn (HR 0.17, CI 0.07-0.43; P<0.0001), diabetes (HR 1.81, CI 1.24-2.47; P¼0.007), CVD (HR 1.86; CI 1.32-2.62; P¼0.007) and UFR (HR 1.22; CI 1.16-1.28; P<0.0001) were identified as factors independently correlated to survival. We estimated the discrimination potential of UFR, evaluated at baseline, in predicting death at 5 years, calculating the relative receiver operating characteristic (ROC) curves and the cut-off that minimizes the absolute difference between sensitivity and specificity. Conclusions. High UFRs are independently associated with increased mortality risk in HD patients. Better survival was observed with UFR<12.37 ml/h/kg BW. For patients with higher UFRs, longer or more frequent dialysis sessions should be considered in order to prevent the deleterious consequences of excessive UFR.
Data 07.01.2008
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