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Titolo Disease severity score could not predict the outcomes in peritoneal dialysis-associated peritonitis
Autore Jie Dong1,*, Zi Li1,2,*, Rong Xu1, Yuan Chen1, Suping Luo1 and Yanjun Li1 1Department of Medicine, Division of Nephrology, Peking University, First Medical Hospital, Peking, China and 2Department of Nephrology, West China Hospital of Sichuan University, Sichuan, People’s Republic of China
Referenza Nephrol Dial Transplant 2012 doi: 10.1093/ndt/gfr654

We aim to explore if disease severity score (DSS) at onset is associated with
dialysate white cell counts, the severity of causative organisms and the risk for
treatment failure of peritoneal dialysis (PD)-associated peritonitis in an
adult PD cohort.

Our prospective cohort study recorded all peritonitis episodes between 2008 and
2010. The DSS, demographic data and clinical characteristics were recorded at
the onset of peritonitis. The dialysate cells were counted at regular intervals
and organism culture were examined too. Treatment failure of peritonitis was defined
as peritonitis-associated death and transfer to haemodialysis.

A total of 219 episodes of peritonitis in 146 PD patients were recorded, 21.9%
of which resulted in treatment failure. There were no significant differences
in dialysate white cell counts on the fifth and seventh day and the
distribution of causative organism between groups with varied DSS level. DSS
could not predict treatment failure including peritonitis-related death and
transfer to haemodialysis after adjusting for age, gender, diabetes, dialysis
duration, dialysate white cell count on the third day, the presence of Staphylococcus
aureus, gram-negative organisms and polymicrobial organisms.

Our study demonstrated that DSS at onset was not associated with prolonged
elevation of dialysate white cell counts, severity of causative organisms and
outcome of peritonitis episodes in adult PD patients.

Data 01.10.2012
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